Sambiloto has clear anti-fertility as well as pregnancy-terminating effects in larger amounts. In India, where Sambiloto is used for common ailments such as diarrhea, fever, and other digestive disorders, it is recommended that the herb be used only for short-term treatment. This is due to the content of compounds that are contraceptive in nature.
The authors of the study done on the rats concluded that the observations suggested an antispermatogenic (sperm production blocking) or antiandrogenic (blocking effects of sex hormones known as androgens) ability of the plant. It should be noted that many herbal extracts have effects on reproductive functions and thus should not be used during pregnancy.